Study of changes in perfusion in the foci of demyelination in multiple sclerosis by perfusion MRI

Introduction . Multiple sclerosis is a chronic immune-mediated disease of the central nervous system with disseminated foci demyelination and progressive neurodegeneration; it most common demyelinating leading cause disability neurological patients young age, characterized by wave-like course alternating periods remission relapse. Currently, there discussion about participation vascular changes in formation disorders possibility correction therapeutic approaches connection revealed microcirculatory disorders. Perfusion MRI allows you to evaluate hemodynamics at capillary level vivo Purpose To perfusion multiple using method dynamic susceptibility contrast (DSC). Materials methods The MR study was carried out on super-high-angle MR-scanner «Ingenia» («Philips») 3 Tesla. included 30 healthy volunteers 80 from 18 48 years old (average age 34,6±8,02 years). Quantitative qualitative assessment indices out. Results. In active demyelination, an increase speed volume cerebral blood flow noted, pronounced clinically isolated syndrome. Inactive foci, marked hypoperfusion noted. Discussion Evaluation new look role component focal inflammatory brain sclerosis, which can determine direction pathogenetic treatment. Conclusion data complements routine provides comprehensive neurovascular system.